A recent study indicates that individuals who stop using new GLP-1 drugs like Mounjaro or Wegovy can put back on lost weight much more quickly than those who halt traditional diet and exercise plans.
Findings released in a prominent health publication points out that while obese people often shed a large proportion of their body weight while on the medication, the mass comes back at an estimated rate of 0.8 kg per month once they quit.
"Users purchasing these treatments must be aware of the danger of quick rebound weight gain when the therapy concludes," warns researcher Dr. Susan Jebb.
Such speed of regain suggests a reversion to pre-treatment weight in about one and a half years.
Weighing Therapies
The analysis, which reviewed dozens of studies involving over 9,000 of patients, contrasted the effects of these new drugs with other pills.
The team emphasize that individuals who shed pounds through lifestyle changes alone usually experience a slower creep back—around 100 grams monthly—once they finish.
Understanding the Fast Regain
Experts propose the mode of action of the jabs accounts for the heightened rebound.
GLP-1 drugs mimic a body's own chemical called GLP-1, which helps regulate appetite.
"Long-term administration of GLP-1 concentrations far above than normal might result in the system to produce less of its own natural hormone, and may also reduce responsiveness to its actions," noted Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication leads to appetite is unsuppressed, making excessive eating a significant risk."
An Ongoing Disease?
Medical guidelines recommend the jabs for people with weight-linked health risks, accompanied by recommended lifestyle changes.
Many experts contend that, considering the significant potential of weight regain, the treatment is often ongoing.
This view is supported by drug manufacturers, who say that the findings "highlight the persistent nature of excess weight," akin to managing conditions like hypertension.
User Testimonies
Users who have discontinued the medication describe a powerful return of appetite.
"It was like a trigger activating and you become starving," described a patient.
This challenge is worsened if individuals have not developed lasting dietary or behavioural modifications during therapy.
Widespread Use
Figures show that millions of people in the UK have used weight-loss jabs in the past year, with demand continuing to grow.
- Use is greater among females than males.
- The 40s and 50s demographic shows the greatest level of interest.
- Many obtain the drugs through private prescriptions rather than the NHS.
Ultimately, researchers stress that while these medications are potent agents for weight loss, they are not a magic fix and maintained weight loss relies on combined lifestyle management.
